Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of the combination of oseltamivir, artificial cow-bezoar, chlorphenamine maleate, and interferon nebulization on immune function in children with influenza

Xianjie Wu¹, Zhimian Liang¹, Xuemei Chen²

¹Department of Pediatrics, The Second Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, China; ²Department of Pediatrics, The Second Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, China.

For correspondence:- Xuemei Chen Email: cxm198632@163.com Tel:+8613876041452

Accepted: 8 October 2023 Published: 31 October 2023

Citation: Wu X, Liang Z, Chen X. Effect of the combination of oseltamivir, artificial cow-bezoar, chlorphenamine maleate, and interferon nebulization on immune function in children with influenza. Trop J Pharm Res 2023; 22(10):2201-2207 doi: 10.4314/tjpr.v22i10.23

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To determine the effect of combining oseltamivir, artificial cow-bezoar, chlorphenamine maleate, and interferon inhalation on immune function and serum amyloid A (SAA) levels in children with influenza.

Methods: A total of 114 children with influenza treated at the Second Affiliated Hospital of Hainan Medical University, Hainan Province, China from December 2019 to December 2022 were randomly divided into two groups, viz, study group (n = 57) and control group (n = 57). Control group received oseltamivir sodium chloride infusion, artificial cow-bezoar, and chlorphenamine maleate granules. Study group was treated with interferon alpha-1b in addition to control group treatment. Their clinical symptoms, duration of symptoms, immune function, SAA and C-reactive protein (CRP) levels were determined before and after treatment. Adverse reactions were also recorded.

Results: Study group had a significantly shorter duration of fever, cough, sore throat, and nasal congestion after 5 days of treatment than control group (p < 0.05). The study group also showed higher CD3+ and CD8+ levels and lower CD4+ and CD4+/CD8+ levels than control group after treatment. However, both groups showed lower levels of SAA, CRP, and SAA/CRP after treatment than before treatment (p < 0.05). Furthermore, the levels of SAA, CRP, and SAA/CRP were lower in study group than in control group after treatment (p < 0.05). The incidence of adverse reactions in the study group after treatment was significantly lower than in the control group (p < 0.05).

Conclusion: Quadruple therapy using oseltamivir, artificial cow-bezoar, chlorphenamine maleate, and interferon inhalation significantly shortens symptoms, boost immunity, lower SAA levels, and reduce side effects in children with influenza.

Keywords: Influenza, Oseltamivir, Artificial cow-bezoar, Chlorphenamine maleate, Interferon, Serum amyloid A, Immune function, Quadruple therapy